The cell membrane of nearly every cell in the human body is made up of cholesterol and phospholipids – essential fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahaexanoic acid). Read Cholesterol is good for you
Omega-3 fatty acids are important for people of all ages – from pregnant women to kids and adults.
From the immune system to the brain, omega-3 plays a critical role in the body’s physiologic processes. For example, the brain is 60% fat – mostly fatty acids; the synapses (the connections between neurons/brain cells) are 80% fatty acids.
So, not only are essential fatty acids critical structural components of our cells, but much of the body’s physiologic function is dependent upon having sufficient essential fatty acids in general and omega-3 in particular.
Humans today eat waaaayyyy too much omega-6 fats, found in processed vegetable oils, grains, and packaged convenience foods.
The ratio of omega-3 to omega-6 in most people is so imbalanced it causes people to be unhealthy, very unhealthy. You can’t say this too much.
Combined with the importance of these essential fatty acids is the fact that our modern culture is terribly deficient in omega-3 essential fatty acids. Because we eat grains and vegetable oils, and because we eat domesticated grain-fed animals, we eat way too much omega-6 fats.
Research has shown that the human body is healthy when our dietary intake of essential fatty acids is a ratio of 1:2 between omega-3 and omega-6.
People today are eating a ratio of 1:30, even 1:50 – it should be 1:2.
Current research shows that people today are eating a diet style of processed vegetable oils such as canola, soy, cottonseed oils (commonly found in packaged foods), and grains (which are high in omega-6), and finally, grain-fed animals, creating ratios today of 1:30, even 1:50 – it should be 1:2.
This gross imbalance of essential fats is resulting in many disease processes among modern cultures – chronic inflammation, atherosclerosis, cancer, and brain degeneration (neurodegenerative diseases or dementia such as Alzheimer’s and Parkinson’s).
Inflammation and Omega-3
When the ratio of omega-6 to omega-3 gets too high, dangerous inflammation results, causing many diseases, including:
- Heart disease
- High Cholesterol
- Autoimmune diseases (Lupus)
- Rheumatoid arthritis
- ADHD (attention deficit hyperactivity disorder)
- Premature and low birth weights
- Neurodegenerative dementia diseases such as Parkinson’s and Alzheimer’s diseases
- Crohn’s disease
- Hypertension (high blood pressure)
- Kremer, Joel M. n-3 fatty acid supplements in rheumatoid arthritis. American Journal of Clinical Nutrition Vol. 71 (suppl), January 2000, pp. 349S-51S
- Cullen, Paul. Evidence that triglycerides are an independent coronary heart disease risk factor. American Journal of Cardiology Vol. 86, November 1, 2000, pp. 943-49
- Stoll, Andrew L., et al. Omega 3 fatty acids in bipolar disorder. Archives of General Psychiatry Vol. 56, May 1999, pp. 407-12 and pp. 415-16 (commentary)
- Calabrese, Joseph R., et al. Fish oils and bipolar disorder. Archives of General Psychiatry Vol. 56, May 1999, pp. 413-14 (commentary)
- Stark, Ken D., et al. Effect of fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy in a placebo-controlled, double-blind trial. American Journal of Clinical Nutrition Vol. 72, August 2000, pp. 389-94
- Fortin, Paul R., et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. Journal of Clinical Epidemiology Vol. 48, 1995, pp. 1379-90
- Cleland, Leslie G. and James, Michael J. Fish oil and rheumatoid arthritis: antiinflammatory and collateral health benefits. Journal of Rheumatology Vol. 27, October 2000, pp. 2305-06 (editorial)
- Arnold, L. Eugene. Alternative treatments for adults with ADHD. Annals of the New York Academy of Sciences Vol. 931, June 2001, pp. 310-41
- Burgess, John R., et al. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. American Journal of Clinical Nutrition Vol. 71 (suppl), January 2000, pp. 171S-175S
- Hu, Frank B., et al. Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women. Circulation Vol. 107, April 15, 2003, pp. 1852-57
- Grundy, Scott M. N-3 fatty acids: priority for post-myocardial infarction clinical trials. Circulation Vol. 107, April 15, 2003, pp. 1834-36 (editorial)
- Rivellese, Angela A., et al. Long-term effects of fish oil on insulin resistance and plasma lipoproteins in NIDDM patients with hypertriglyceridemia. Diabetes Care Vol. 19, November 1996, pp. 1207-13
- Olsen, Sjurour Frooi and Secher, Niels Jorgen. Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study. British Medical Journal Vol. 324, February 23, 2002, pp. 1-5
- Carlson, S.E. Long-chain polyunsaturated fatty acids and development of human infants. Acta Paediatr Suppl, No. 430, 1999, pp. 72-7
- Cunnane, Stephen C., et al. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids Vol. 35, January 2000, pp. 105-11
- Mayser, Peter, et al. Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multi-center trial. Journal of the American Academy of Dermatology Vol. 38, April 1998, pp. 539-47
- Escobar, S.O., et al. Topical fish oil in psoriasis: a controlled and blind study. Clinical and Experimental Dermatology Vol. 17, 1992, pp. 159-62
- Wu A, Ying Z, Gomez-Pinilla F Docosahexanoic Acid Dietary Supplementation Enhances the Effects of Exercise on Synaptic Plasticity and Cognition. Neuroscience 2008; 155(3):751-9.
- Chytrova G, Ying Z, Gomez-Pinilla F Exercise Contributes to the Effects of DHA Dietary Supplementation by Acting on Membrane-Related Synaptic Systems Brain Research 2010 Jun 23;1341:32-40
- Jouris K, McDaniel J, Weiss E. The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to Eccentric Strength Exercise Journal of Sports Science and Medicine 2011;10:432-438.
- Bailes J, Mills J. Docosahexanoic Acid Reduces Traumatic Axonal Injury in a Rodent Head Injury Model Journal of Neurotrauma 2010; 27:1617-1626.
- Guilliams T. The Use of Fish Oil Supplements in Clinical Practice: A Review”. Journal of the American Nutraceutical Association 2005; 8(1).
- Gomez-Pinilla F, Ying Z Differential Effects of Exercise and Dietary Docosahexaenoic Acid on Molecular Systems Associated with Control of Allostasis in the Hypothalamus and Hippocampus Neuroscience 2010;168(1): 130-7.
- Antonio J, Kalman D, Stout J, Greenwood M, Willoughby D, Haff G Essentials of Sports Nutrition and Supplements. Publisher: Springer 2008;268-270.
- Kris-Etherton P, William H, Appel L Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease Journal of The American Heart Association 2002; 106:2747-2757
- Pottala, James V. PhD Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes Neurology (2014) First published online before print January 22, 2014 doi: 10.1212.
- Tan, ZS, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology Feb 28, 2012 vol. 78(9):658-664
- Cederholm, T Fish consumption and omega-3 fatty acid supplementation for prevention or treatment of cognitive decline, dementia or Alzheimer’s disease in older adults – any news? Current Opinion in Clinical Nutrition and Metabolic Care: March 2017, 20: 2;104–109